Use of "Despite" and "In spite of"

despite

এ দুটোই Preposition হিসেবে কাজ করে অর্থাৎ কোন Word কিংবা Phrase কে সংযুক্ত করে। আরেকটা লক্ষ্যণীয় ব্যাপার despite এর সাথে কখনই  of ব্যবহার করা যাবে না।

For Example:

Despite his denial, we know that he was guilty.

In spite of his denial, we know that he was guilty.

Despite his physical handicap, he has become a successful businessman.

In spite of his physical handicap, he has become a successful businessman.

 Jane will be admitted to the university despite her bad  grades.